Site under construction (Please come back soon -- last updated September 7, 2021)
Structure and Function of Biological Macromolecules
- Our primary research interest is in understanding how biological macromolecules function at the molecular level.
- Our lab is particularly interested in understanding how the three-dimensional structures of proteins have evolved to act as highly specific and efficient chemical catalysts (enzymes) or binding proteins.
- The main techniques that we use for our studies are molecular biology, protein expression and purification, and X-ray crystallography.
Tools for predicting and analysing protein structures
- CCharPPI -- Computational Characterization of Protein-Protein Interfaces
- SKEMPI -- Structural Database of Kinetics and Energetics of Mutant Protein Interactions V. 2.0
- Zhang Lab -- On-line webserver tools from Professor Yang Zhang's Lab at the University of Michigan
- PSIPRED -- On-line webserver tools from Professor David Jones' Lab at University College London
- RPBS -- On-line tools from Ressource Parisienne en Bioinformatique Structurale at Institut Pasteur
- Sparks Lab -- Protein sequence/structure analysis tools from Professor Yaoqi Zhou at Griffith University
- Robetta -- Protein sequence/structure prediction from Professor David Baker at University of Washington