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Structure and Function of Biological Macromolecules

  • Our primary research interest is in understanding how biological macromolecules function at the molecular level. 
  • Our lab is particularly interested in understanding how the three-dimensional structures of proteins have evolved to act as highly specific and efficient chemical catalysts (enzymes) or binding proteins.
  • The main techniques that we use for our studies are molecular biology, protein expression and purification, and X-ray crystallography.

News!

  • ​Marangoni et al, 2020 -- Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity (Youtube video kindly provided by Dr. Sui-Lam Wong, University of Calgary)
  • ​Lang et al, 2019 -- Structure–function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition
  • Canadian Light Source -- press release

Tools for predicting and analysing protein structures

  • ​CCharPPI -- Computational Characterization of Protein-Protein Interfaces
  • SKEMPI -- Structural Database of Kinetics and Energetics of Mutant Protein Interactions V. 2.0
  • Zhang Lab -- On-line webserver tools from Professor Yang Zhang's Lab at the University of Michigan
  • PSIPRED -- On-line webserver tools from Professor David Jones' Lab at University College London
  • RPBS -- On-line tools from Ressource Parisienne en Bioinformatique Structurale at Institut Pasteur
  • Sparks Lab -- Protein sequence/structure analysis tools from Professor Yaoqi Zhou at Griffith University
  • Robetta -- Protein sequence/structure prediction from Professor David Baker at University of Washington

Ligand docking

  • ZINCPharmer -- Pharmacophore searching server from David Koes at the University of Pittsburgh
  • PocketQuery -- Protein interface pockets from David Koes

Journal Indexes

General Interest Scientific Journals

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